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Aim: To prove the relationship between TIL expression and clinic-pathology in the luminal A subtype and TNBC subtype along with the presence or absence of differences between the two subjects. Methods: This study was an observational study, designed in a cross-sectional manner at Sanglah Hospital Denpasar. Inclusion criteria were breast cancer patients with luminal A subtype and TNBC (triple negative breast cancer) subtype as research subjects. Results: In this study there were 31 subjects with Luminal A and 40 subjects with TNBC. This study found a significant relationship between stage and TIL levels in breast cancer subtype TNBC (p=0.01). In high-grade TNBC breast cancer subtype, the possibility of TIL is high 3 times compared with subjects with stage I-II. There was a significant relationship in patients with high TIL with advanced stages in the TNBC subtype and luminal A (p=0.028; PR 1.8; 95% CI 0.54-5.9). Conclusion: No significant relationship was obtained between TIL and tumour size, clinical stage, histopathological grade in breast cancer in luminal A and TNBC subtypes. There is also no relationship between tumour size and tumour grading between breast cancer with TNBC subtype and luminal A which have high TIL, but there are differences in tumour stage.

Hubungan Ekspresi Tumor Infiltrating Lymphocytes dengan Klinikopatologi pada Subtipe Luminal A dan Triple Negative Kanker Payudara di Bali