English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Effects of lipid A analogues of the strains of E. coli on complement and myeloperoxidase activation in myocardial reperfusion following ischaemia in rats The aim of the study was to evaluate the ability of lipid A analogues obtained from the native strain (LAS) or strains of E. coli resistant to either an amine oxide (modLANO) or to a quaternary ammonium salt (modLBr) to reduce myocardial ischaemia and reperfusion injury in rats. The 0.5, 2, 4, 24 h pretreatment of rats with lipid A from a strain of E. coli resistant to an amine oxide (modLANO 0.5 mg/kg i.v.) in an in vitro model of myocardial ischemia lasting 10 min followed by 10 min reperfusion did not reduce the myeloperoxidase (MPO) and complement activities. In an in vivo study, the 24 h pretreatment of rats with modLANO in a dose of 0.5 mg/kg i.v. only significantly decreased both the MPO and complement activities in serum (p<0.01). The analogues of lipid A indicate abilities to influence the myocardial ischaemia-reperfusion injury in times-dependent and structures-dependent ways. Vplyv analógov lipidu a kmeňov E. coli na komplementovú a myeloperoxidázovu aktiváciu počas reperfúzie po ischémii srdca potkanov Cieľom práce bolo zistiť, či analógy lipidu A získané z natívneho kmeňa (LAS), a z kmeňa E. coli rezistentného na amínoxid (modLANO) alebo na kvartérnu amóniovú soľ (modLBr) znižujú ischemicko - reperfúzne poškodenie srdca potkanov. Lipid A z rezistentného kmeňa E. coli na amínoxid (modLANO 0,5 mg/kg i.v.) neznížil v in vitro pokusoch po 10 minút trvajúcej ischémii srdca a následnej 10 min reperfúzii myeloperoxidázovú (MPO) ani komplementovú aktivitu pri rôznej dlžke predliečenia (0,5, 2, 4, 24 h) potkanov. V in vivo pokusoch 24 h predliečenie potkanov s modLANO v dávke 0,5 mg/kg i.v. významne znížilo MPO aj komplementovú aktivitu v sére (p<0,01). Analógy lipidov A prejavili schopnosť ovplyvniť poškodenie myokardu v podmienkach ischémie a reperfúzie v závislosti od času pôsobenia a ich štruktúry.

acta facultatis pharmaceuticae universitatis comenianae

Effects of lipid A analogues of the strains of E. coli on complement and myeloperoxidase activation in myocardial reperfusion following ischaemia in rats