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Summary Guinea pigs were intoxicated intramuscularly with different doses of soman, and cholinesterase activities were determined in the blood, diaphragm and parts of the brain – the pontomedullar area, the frontal cortex and the basal ganglia. The time course of poisoning following low doses (1,3, 5 μg/kg) and a dose equal to 1×LD 50 (28.5 μg/kg) were studied. The dose having a negligible effect on cholinesterases in the tissues studied was assessed at 1–3 μg/kg, and, following administration of a dose of 5 μg/kg, statistically significant blood cholinesterase inhibition was demonstrated.

Inhibition of blood and tissue cholinesterases by soman in guinea pigs in vivo