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Recent complexity-theoretic results on finding c-optimal designs over finite experimental domain X are discussed and their implications for the analysis of existing algorithms and for the construction of new algorithms are shown. Assuming some complexity-theoretic conjectures, we show that the approximate version of c-optimality does not have an efficient parallel implementation. Further, we study the question whether for finding the c-optimal designs over finite experimental domain X there exist a strongly polynomial algorithms and show relations between considered design problem and linear programming. Finally, we point out some complexity-theoretic properties of the SAC algorithm for c-optimality.

On computational complexity of construction of c -optimal linear regression models over finite experimental domains