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Dietary modulation of immune responses by ascorbic acid in healthy and cadmium-induced immunocompromised chickens The assessment of immunological changes induced in chickens by feeding 50 mg cadmium per 1 kg of diet from hatching to 30 days of age was studied. Furthermore, the modulatory effects of different supplemental doses of ascorbic acid (100 and 1000 mg per 1 kg of diet) were investigated. The observed immunocompromise in chickens continuously exposed to cadmium resulted in a decreased growth rate and disturbance of immune responses, both on nonspecific and specific levels. The effect of supplements 100 and 1000 mg of ascorbic acid per 1 kg of diet differed. The low dosage of ascorbic acid had immunostimulative action in healthy cadmium-untreated chickens, provided correction of compromised immunity, and increased tolerance of the birds to subtoxic cadmium intake. In contrast, the higher supplement of ascorbic acid had a slight or no effect on healthy birds and either caused no significant shifts in immunological indices or manifested synergistic effect combined with cadmium.

proceedings of the latvian academy of sciences. section b, natural sciences/latvijas zinātņu akadēmijas vēstis. a daļa, humanitārās un sociālās zinātnes