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Neopterin, cellular adhesion molecules and myeolperoxidase in patients with stable and unstable angina pectoris Recent data indicate that the serum level of neopterin, a marker of inflammation and immune modulator secreted by monocytes/macrophages, is elevated in patients with acute coronary syndrome (ACS) and seems to be a prognostic marker for major cardiovascular events. Soluble cellular adhesion molecules (sCAMs) and myeloperoxidase (MPO) levels are also related to ACS. The aim of the present study was to evaluate differences in serum levels of neopterin, sCAMs and MPO between coronary artery disease and metabolic syndrome (CAD-MetS) patients with stable and unstable angina pectoris (SAP, UAP), and to clarify the relationships between neopterin and other biomarkers. The study included 60 patients with CAD-MetS who were classified into two groups, 30 patients with SAP and 30 patients with UAP. Twenty healthy subjects were selected as controls (C). Serum soluble vascular cell adhesion molecule-1 (sVCAM-1), intercellular cell adhesion molecule-1 (sICAM-1), sE-selectin and MPO levels were measured by Luminex xMAP technology, and serum neopterin concentrations were measured by radioimmunoassay. Results: Serum levels of neopterin, MPO, sVCAM-1, sICAM-1, and sE-selectin were significantly higher in patients with UAP in comparison with the group of healthy controls (P < 0.05). Patients with SAP also had higher levels of these biomarkers than those in healthy controls (P < 0.05), except for sE-selectin. The biomarker level did not differ between the two patient groups, except for MPO, which was significantly higher in the USP group (P < 0.05). Neopterin was significantly correlated only with sVCAM-1 (P < 0.05). In conclusion, CAD-Met patients with SAP had more apparent raised levels of serum sICAM-1 and sVCAM-1, simultaneously with higher MPO and neopterin concentrations, in comparison to those in healthy subjects. However, UAP is also associated with more substantial changes in MPO and significantly increased sE-selectin levels. Neopterin concentration was had a close correlation only with sVCAM-1. Neopterīns, šūnu adhēzijas molekulas un mieloperoksidāze pacientiem ar stabilu un nestabilu stenokardiju Mūsdienu pētījumi liecina, ka pacientiem ar akūtu koronāro sindromu (ACS) ir palielināta neopterīna koncentrācija asins serumā un tā spēj kalpot kā prognostisks biomarķieris kardiovaskulāriem notikumiem. Seruma šķīstošo šūnu adhēzijas molekulu (sCAMs) un mieloperoksidāzes (MPO) koncentrācijas palielināšanās arī ir saistīta ar ACS. Šī pētījuma mērķis bija novērt¯t atšķirības neopterīna, sCAMs un MPO seruma koncentrāciju atšķirības koronārās sirds slimības un metabolā sindroma pacientiem (CAD-MetS) ar stabilu un nestabilu stenokardiju (SAP, UAP), kā arī noskaidrot neopterīna saistību ar minētajiem biomarķieriem. Pētījumā tika iesaistīti 60 CAD-MetS pacienti, no kuriem 30 bija ar SAP un 30 ar UAP. 20 veseli voluntieri tika iekļauti kontroles grupā (C). Seruma šķīstošo vaskulāro šūnu adhēzijas molekulu-1 (sVCAM-1), intracelulāro šūnu adhēzijas molekulu-1(sICAM-1), šķīstošā E-selektīna (sE-selectin) un MPO koncentrācijas tika noteiktas ar Luminex xMAP tehnologiju, bet seruma neopterīna koncentrācija - radioimunologiski. Seruma neopterīna, MPO, sVCAM-1, sICAM-1 un sE-selectin koncentrācijas bija statistiski ticami augstākas pacientiem ar UAP, salīdzinot ar C grupu (P < 0.05). Pacientiem ar SAP arī bija būtiski augstāka minēto biomarķieru koncentrācija serumā nekā veseliem voluntieriem, izņemot sE-selectin koncentrācijas, kas neatšķīrās. Pētījuma biomarķieru koncentrācijas neatšķīrās starp pacientu grupām, izņemot MPO koncentrāciju, kas bija būtiski lielāka USP pacientu grupā (P < 0.05). Neopterīna koncentrācijas būtiski korelēja tikai ar sVCAM-1 koncentrācijām (P < 0.05). Tādējādi CAD-MetS pacientiem ar SAP ir būtiskāk izteikts sVCAM-1 un sICAM-1 seruma koncentrāciju palielinājums, vienlaikus, lielākas neopterīna un MPO koncentrācijas, bet UAP saistīts ar vēl būtiskāku MPO un sE-selectin koncentrāciju palielināšanos, salīdzinot ar veseliem voluntieriem. Seruma neopterīnam ir cieša korelācija tikai ar sVCAM-1.

proceedings of the latvian academy of sciences. section b, natural sciences/latvijas zinātņu akadēmijas vēstis. a daļa, humanitārās un sociālās zinātnes