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Association of Interleukin 6 Promoter Polymorphism (-174G/C) with IL-6 Level and Outcome in Severe Sepsis Interleukin (IL-6) is a key cytokine in the pathogenesis of severe sepsis. The importance of a regulatory polymorphism within the IL-6 promoter remains unclear in these patients. The aim of the study was to determine if IL-6 (-174 G/C) promoter polymorphism has an effect on IL-6 plasma level and outcome of severe sepsis. The study was conducted in general ICU of Stradiñš Clinical University Hospital. A total of 103 critically ill patients with confirmed severe sepsis were prospectively included. Association analysis of the IL-6 (-174C) allele with serum level and clinical outcome was performed. We found no differences in genotype distribution between survivors and nonsurvivors. The serum IL-6 level was significantly higher in nonsurvivors compared with survivors. We found an association of genotype with the IL-6 level in nonsurvivors, but not in survivors. Our findings show a functional significance of IL-6 promoter polymorphisms in nonsurviving severe sepsis patients. Interleikīna 6 (IL-6) Gēna (-174 G/C) Promotera Polimorfisma Asociācija AR IL-6 Līmeni Un Klīnisko Iznākumu Smagas Sepses Slimniekiem Interleikīns 6 (IL-6) ir nozīmīgs citokīns smagas sepses patogenēzē. IL-6 gēna promotera polimorfisma klīniskā nozīme smagas sepses slimniekiem arvien paliek neskaidra. Pētījuma mērķis ir noskaidrot IL-6 gēna promotera (-174 G/C) polimorfisma ietekmi uz IL-6 sistēmisko līmeni un klīnisko iznākumu smagas sepses slimniekiem. Pētījumā tika iekļauti 103 Paula Stradiña Klīniskās universitātes slimnīcas Intensīvās terapijas un reanimācijas nodaļas slimnieki ar apstiprinātu smagas sepses diagnozi. Pētījuma rezultātā nav konstatētas genotipu sadalījuma atšķirības izdzīvojušiem un mirušajiem smagas sepses slimniekiem. Novērota augstāka IL-6 plazmas koncentrācija mirušo slimnieku apakšgrupā. Genotipu saistība ar IL-6 plazmas līmeni konstatēta mirušo slimnieku apakšgrupā. Pētījuma rezultāti liecina par IL-6 (-174 G/C) polimorfisma funkcionālo nozīmīgumu neizdzīvojušiem smagas sepses slimniekiem.

proceedings of the latvian academy of sciences. section b, natural sciences/latvijas zinātņu akadēmijas vēstis. a daļa, humanitārās un sociālās zinātnes