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Summary Cholesterol biosynthesis is a complex pathway comprising more than 20 biochemical reactions. Although the final product created in the pathway is cholesterol, the intermediate products, such as ubiquinone and dolichol, also provide vital metabolic functions. Statins are HGM-CoA reductase inhibitors that stop the production of cholesterol by directly inhibiting the mevalonate production. Mevalonate is a precursor of two additional vital molecules, squalene and ubiquinone (coenzyme Q10). We hypothesized that inhibiting the cholesterol biosynthesis with statins for an extended duration may potentiate the oxidative stress, neurodegenerative disease and cancer. Our recommendation was to measure muscle enzymes, antioxidant capacity, and ubiquinone to monitor patients receiving the statins for prolonged periods of time. Kratak sadržaj Biosinteza holesterola je kompleksan metabolički put koji obuhvata više od 20 biohemijskih reakcija, lako je konačan proizvod koji nastaje holesterol, intermedijerni proizvodi, kao što su ubihinon i dolihol, takođe obezbeđuju vitalne metaboličke funkcije. Statini su inhibitori HMG-KoA reduktaze koji zaustavljaju produkciju holesterola direktnom inhibicijom produkcije mevalonata. Mevalonat je prekursor dva dodatna vitalna molekula, skvalena i ubihinona (koenzim Q10). Postavili smo hipotezu da produženo trajanje inhibicije biosinteze holesterola statinima može da potencira oksidativni stres, neurodegenerativne bolesti i kancer. Takođe preporučujemo određivanje mišićnih enzima, antioksidativnog kapaciteta i ubihinona u praćenju pacijenata koji primaju statine u dužem vremenskom periodu.

journal of medical biochemistry

Inhibition of Cholesterol Biosynthesis in Hypercholesterolemia – Is It the Right Choice? / Inhibicija Biosinteze Holesterola u Hiperholesterolemiji – Da Li Je Pravi Izbor?