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Biomarkers for Diabetes Complications: The Results of Several Clinical Studies Diabetes is a common metabolic disorder. Its microvascular and macrovascular complications contribute to death, disabilities, and reduction in life expectancy in diabetes. It is a costly disease, and affects not only the patient and family, but also the public health, communities and society. It takes an increasing proportion of the national health care expenditure. The prevention of the development of diabetes and its complications is a major concern. Biomarkers have been investigated for understanding the mechanisms of the development and progression of diabetic complications. In this paper, the biomarkers which are recommended in the clinical practice and laboratory medicine guidelines, and which have been investigated for prediction or diagnosis of diabetes complications, have been reviewed. The results of several clinical studies will be summarized. Biomarkeri Komplikacija u Dijabetesu: Rezultati Nekoliko Kliničkih Studija Dijabetes predstavlja čest metabolički poremećaj, čije mikrovaskularne i makrovaskularne komplikacije doprinose smrti, invaliditetu i skraćenju očekivanog životnog veka kod obolelih. Ova bolest podrazumeva velike troškove a pored pacijenta i njegove porodice pogađa i javno zdravlje, zajednice i društvo. Dijabetes zahteva sve veći deo nacionalnih troškova zdravstva. Prevencija razvoja dijabetesa i njegovih komplikacija je važan problem. U cilju razumevanja mehanizama razvoja i progresije komplikacija u dijabetesu vrši se istraživanje biomarkera. U ovom radu dat je pregled biomarkera koji se preporučuju u kliničkoj praksi i pravilnicima za laboratorijsku medicinu i koji su istraživani radi predikcije ili dijagnostikovanja komplikacija u dijabetesu. U sažetom obliku su prikazani rezultati nekoliko kliničkih studija.