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N-Terminal Pro-B-Type Natriuretic Peptide in Patients with Hypertensive Heart Disease Patients with hypertensive heart disease have elevated concentrations of N-terminal pro-B-type natriuretic peptide (NT-proBNP). The aim of our study was to evaluate NT-proBNP in patients with long-standing hypertension and in patients with signs of hypertensive cardiomyopathy. The study included three groups of 50 subjects: healthy persons (Control Group), patients with hypertension and normal left ventricular systolic function (Group 1) and patients with longstanding hypertension and signs of hyper tensive cardiomyopathy with impaired left ventricular systolic function (Group 2). Our results show a very good correlation (Pearson's test) between NT-proBNP in Group 1 and Group 2 and C-reactive protein (Group 1: r = 0.8424; Group 2: r = 0.6650), systolic blood pressure (Group 1: r = 0.7213; Group 2: r = 0.4856), diastolic blood pressure (Group 1: r = 0.4282; Group 2: r = 0.3989) and ejection fraction (Group 1: r = -0.7390; Group 2: r = 0.9111). ROC analysis revealed that the AUC between the Control Group and Group 1 for NT-proBNP (0.912) was not significantly different (p>0.05) from the AUC for systolic (0.924) and diastolic pressure (0.937). A cut-off value for NT-proBNP of 5.89 pmol/L can be used to reliably distinguish patients of Group 1 from the Control Group, and a cut-off value of 21.67 pmol/L reliably separates patients from Group 1 and Group 2 (in both cases, the AUC is 1.000). Patients in Group 2 who belonged to the II and III New York Heart Association (NYHA) class had significantly higher levels of NT-proBNP than those in NYHA class I (ANOVA test, p=0.001). These data suggest that NT-proBNP is a useful biomarker for distin guishing patients with long-standing hypertension who are at risk of heart failure, allowing optimization and proper treatment of these patients. N-Terminalni Pro-B-Tip Natriuretskog Peptida Kod Pacijenata sa Hipertenzivnim Srčanim Oboljenjima Pacijenti sa hipertenzivnim srčanim oboljenjima imaju povišene koncentracije N-terminalnog pro-B-tipa natriuretskog peptida (NT-proBNP). Cilj rada bio je da se izvrši evaluacija razlika u NT-proBNP kod pacijenata sa dugogodišnjom arterijskom hipertenzijom i znacima hipertenzivne kardiomiopatije. Ispitivanje je obuhvatilo tri grupe sa po 50 ispitanika: zdrave osobe (kontrolna grupa), pacijente sa arterijskom hipertenzijom i normalnom sistolnom funkcijom leve komore (grupa 1) i pacijente sa dugogodišnjom arterijskom hipertenzijom i znacima hipertenzivne kardiomiopatije sa oslabljenom sistolnom funkcijom leve komore (grupa 2). Dobijeni podaci pokazali su da NT-proBNP u grupi 1 kao i u grupi 2 veoma dobro koreliše (Pearsonov test) sa CRP (grupa 1: r = 0,8424; grupa 2: r = 0,6650), sistolnim pritiskom (grupa 1: r = 0,7213; grupa 2: r = 0,4856), dijastolnim pritiskom (grupa 1: r = 0,4282; grupa 2: r = 0,3989) i ejekcionom frakcijom (grupa 1: r = -0,7390; grupa 2: r = 0,9111). ROC analiza je pokazala da se AUC izme u kontrolne grupe i grupe 1 za NT-proBNP (0,912) značajno ne razlikuje (p > 0,05) od AUC za sistolni (0,924) i dijastolni pritisak (0,937). Na osnovu cutoff vrednosti za NT-proBNP od 5,89 pmol/L mogu se pouzdano razlikovati pacijenti u grupi 1 od kontrol ne grupe, dok se pomoću cutoff vrednosti od 21,67 pmol/L pouzdano razdvajaju pacijente iz grupe 1 i grupe 2 (u oba slučaja AUC su 1,000). Pacijenti u grupi 2 koji su pripadali II i III New York Heart Association (NYHA) klasi su imali značajno više vrednosti NT-proBNP od onih u I NYHA klasi (ANOVA test, p = 0,001). Ovi podaci ukazuju na to da je NT-proBNP koristan biomarker za razlikovanje pacijenata sa dugogodišnjom arterijskom hipertenzijom kojima preti zastojna srčana slabost, što omogućava optimizaciju i adekvatan tretman ovih pacijenata.