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Inhibition of Central Angiotensin Converting Enzyme Exerts Anxiolytic Effects by Decreasing Brain Oxidative Stress This study investigated the effects of angiotensin II and captopril intracerebroventricular administration on anxiety status and brain oxidative stress. Elevated plus maze was used in order to asses the anxiety-like behavior, while the biochemical analysis included the determination of some antioxidant defense enzymes like superoxide dismutase and glutathione peroxidase and also a lipid peroxidation product (malondialdehyde). Our results provide additional evidence of angiotensin II induced anxiety-like effects and increased prooxidant status. Moreover, the blockade of angiotensin II, by the administration of an angiotensin converting enzyme inhibitor (captopril) resulted in anxiolytic effects and decreased oxidative stress status. In addition, we found a significant correlation between the time spent by rats in the open arms of the elevated plus maze and oxidative stress markers. This could raise important therapeutic issues regarding the anxiolytic effects of some angiotensin converting enzyme inhibitors used primarily for hypertension, such as captopril. Also, it seems that oxidative stress could play an important part in these actions. Inhibicija Centralnog Enzima Koji Konvertuje Angiotenzin Deluje Kao Anksiolitik Smanjujući Oksidativni Stres u Mozgu Ispitivan je uticaj intracerebroventrikularne administracije angiotenzina II i kaptoprila na napetost i oksidativni stres u mozgu. Za procenjivanje ponašanja bliskog anksioznosti korišćen je test uzdignutog lavirinta u obliku znaka plus, dok je biohemijska analiza obuhvatila određivanje nekih enzima antioksidantne odbrane kao što su superoksid-dismutaza i glutation-peroksidaza i proizvoda lipidne peroksidacije (malondialdehid). Naši rezultati predstavljaju još jedan dokaz da angiotenzin II izaziva posledice nalik na anksioznost i povišen prooksidantni status. Štaviše, blokiranje angiotenzina II davanjem inhibitora enzima koji konvertuje angiotenzin (kaptoprila) delovalo je kao anksiolitik i dovelo do sniženja statusa oksidativnog stresa. Pored toga, otkrivena je značajna korelacija između vremena koje su pacovi proveli u otvorenim »rukama« lavirinta i markera oksidativnog stresa. Ovo možda ukazuje na važnost pokretanja nekih važnih terapijskih pitanja koja se tiču anksiolitičkog dejstva nekih inhibitora enzima koji konvertuju angiotenzin a koji se pre svega koriste za hipertenziju, kakav je kaptopril. Takođe, sva je prilika da oksidativni stres u tome igra važnu ulogu.