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Automation, Lean, Six Sigma: Synergies for Improving Laboratory Efficiency The Pathology Services worldwide, surrounded by products are today requesting solutions. The approach aims towards the brain-to-brain cycle between caregivers and laboratory professionals. Despite budgets limited to 2-3% of total healthcare expenses, Laboratories are providing information for > 70% of medical actions. »Perianalytics« is becoming the focus; understanding information and sample flow in the whole journey and processes. Process analysis is the main component to understand and shape the best combination of components in designing a truly cost-effective Laboratory solution. Methodologies like Lean (or Toyota Production System) and Six Sigma have started recently to be adopted also in healthcare and in the Laboratory environment. Those techniques showed already successful implementations in healthcare, after their development in other sectors. Their tools are addressing the definition of »value«, »waste«, »flow« as key drivers to improve performances. The synergy among the methods allows decision makers to identify the degree of automation really necessary in their laboratory, with streamlined processes. The different platforms made available by industries, for in vitro diagnostic testing, could become not cost-effective or efficient without a careful assessment of needs, pathways and value-related variables. Total laboratory automation or stand-alone islands for systems can be identified and chosen after process mapping and recommendations deployed with Lean and Six Sigma techniques. This article highlights some key concepts of Lean and their fit in laboratory organization, as methodologies to be implemented before selecting and adopting automated systems. Automatizacija, Lean, Six Sigma: Sinergija U Poboljšanju Laboratorijske Efikasnosti Patološke službe širom sveta, okružene proizvodima, tragaju za rešenjima. Pristup cilja na ciklus bliske saradnje između medicinskih radnika i laboratorijskih stručnjaka. Uprkos budžetima ograničenim na 2-3% ukupnih troškova zdravstva, laboratorije pružaju informacije za > 70% medicinskih postupaka. »Perianalitika« postaje fokus, razumevanje protoka informacija i uzoraka kroz čitavo putovanje i procese. Analiza procesa je glavna stavka za razumevanje i oblikovanje najbolje kombinacije komponenata u dizajniranju finansijski zaista povoljnog rešenja za laboratoriju. Metodologije poput Lean (ili Toyota Production System) i Six Sigma nedavno su počele da se usvajaju u zdravstvu kao i u laboratorijskom okruženju. Posle razvoja u drugim sektorima, te tehnike su u zdravstvu pokazale uspešnu primenu. Njihove alatke obraćaju se definicijama »vrednosti«, »otpada«, »protoka« kao ključnim pokretačima za poboljšanje performansi. Sinergija između metoda dozvoljava donosiocima odluka da prepoznaju koji je stepen automatizacije stvarno potreban u njihovoj laboratoriji, uz modernizovane procese. Različite platforme napravljene u industriji, za in vitro dijagnostičko testiranje, mogle bi postati finansijski nepristupačne i neefikasne bez pažljive procene potreba, putanja i varijabli vezanih za vrednost. Ukupna laboratorijska automatizacija ili samostalna »ostrva« za sisteme mogu se identifikovati i izabrati posle mapiranja procesa i preporuka primenjenih u tehnikama Lean i Six Sigma. Ovaj članak ističe neke ključne koncepte Leana i njegovog mesta u laboratorijskoj organizaciji, kao metodologije koju treba implementirati pre odabira i usvajanja automatizovanog sistema.