English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Bone Turnover Markers Relations to Postmenopausal Osteoporosis Osteoporosis is a systemic disease characterized by low bone mass and high bone turnover markers in postmenopausal women (PM). The relationship between biochemical bone markers C-telopeptides of type 1 collagen (CTX) and osteocalcin (OC), and bone mineral density (BMD) in the postmenopausal period was examined in 104 PM women divided into three groups according to their BMD: group A - control PM with normal bone density, group B - osteopenic PM and group C - osteoporotic PM. Mean CTX values were highest in group C (0.54±0.24 ng/mL) compared to group B (0.44±0.21 ng/mL) (p<0.0001), and group A (0.33±0.13 ng/mL) (p<0.029). Mean OC levels in group C (26.83±9.91 ng/mL) were significantly higher compared to group A (20.47±7.03 ng/mL) (p<0.011) but not significantly higher compared to group B (24.11±8.38 ng/mL) (p>0.05). Postmenopause duration was longest in group C (13.1±8.31 yrs) compared to group B (9.6±6.24 yrs), and group A (8.15±6.86 yrs). Postmenopausal women developed osteoporosis with longer menopause duration. PM osteoporotic women were characterized by increased levels of bone turnover markers indicating increased rate of bone remodeling, which resulted in excessive bone resorption, and loss of bone mass. Long-term persistence of high bone resorption marker CTX, insufficiently compensated with bone formation marker OC, enabled osteoporosis development. Odnosi Između Markera Koštanog Prometa i Postmenopauzalne Osteoporoze Osteoporoza je sistemska bolest koju karakterišu nizak nivo markera koštane mase i visok nivo markera koštanog prometa kod žena u postmenopauzi (PM). Odnos između biohemijskih koštanih markera, C-telopeptida kolagena tipa 1 (CTX) i osteokalcina (OC), i mineralne gustine kostiju (BMD) u periodu postmenopauze ispitivan je kod 104 žene u PM koje su prema BMD podeljene u tri grupe: grupa A - kontrolna grupa žena u PM sa normalnom gustinom kostiju, grupa B - žene u PM sa osteopenijom, i grupa C - žene u PM sa osteoporozom. Prosečne vrednosti CTX bile su najviše u grupi C (0,54±0,24 ng/mL), u poređenju sa grupom B (0,44±0,21 ng/mL) (p>0,0001) i grupom A (0,33±0,13 ng/mL) (p>0,029). Srednje vrednosti OC bile su značajno više u grupi C (26,83±9,91 ng/mL) u poređenju sa grupom A (20,47±7,03 ng/mL) (p>0,011), ali ne i značajno više u poređenju sa grupom B (24,11±8,38 ng/mL) (p>0,05). Trajanje postmenopauze bilo je najduže u grupi C (13,1±8,31 god.) u poređenju sa grupom B (9,6±6,24 god.) i grupom A (8,15±6,86 god.). Žene u postmenopauzi sa dužim trajanjem menopauze dobile su osteoporozu. Žene u PM sa osteoporozom imale su povišene nivoe markera koštanog prometa što je ukazalo na povišenu stopu koštanog remodelovanja, čiji je rezultat preterana koštana resorpcija, i gubitak koštane mase. Dugotrajno prisustvo visokih nivoa markera koštane resorpcije CTX, uz nedovoljnu kompenzaciju od strane markera za formiranje kostiju OC, omogućilo je razvoj osteoporoze.