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The interactions of metal complexes with important biomolecules such as deoxyribonucleic acid (DNA) or bovine serum albumin (BSA) are responsible for their antitumor activity due to different modes of interaction with DNA and their transport through the blood system to cells and tissues via serum albumin. Therefore, the dinuclear palladium(II) complexes, [{Pd(en)Cl} 2 (μ-1,5- nphe)](NO 3 ) 2  ( Pd1 ) and [{Pd(1,3-pd)Cl} 2 (μ-1,5-nphe)](NO 3 ) 2  ( Pd2 ) (en is ethylenediamine, 1,3-pd is 1,3-propylenediamine and 1,5-nphe is the bridging 1,5-naphthyridine ligand) were synthesized and characterized by different spectroscopic methods. The UV-Vis and fluorescence emission spectroscopy were applied for evaluation of binding modes of  Pd1  and  Pd2  complexes to DNA as well as their interaction with BSA. The emission spectra indicate that the investigated  Pd1  and  Pd2  complexes can displace the ethidium bromide intercalator from DNA/EtBr molecules and act as intercalators showing strong interactions with DNA. The fluorescence intensity showes that  Pd1  and  Pd2  complexes can bind to BSA and then be transported to the cell.

DNA-and BSA-Binding Studies of Dinuclear Palladium(II) Complexes with 1,5-Naphtiridine Bridging Ligands