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Yuri Gagarin has started the first time in human history the manned mission in space when his Vostok aircraft successfully achieved Earth orbit in 1961. Since his times, human space programs did not develop too much, and the biggest achievement still remain landing on the Moon. Despite this stagnation, there are serious plans to launch manned mission to Mars including human space settlement. In out paper, we are going to identify and discuss a couple of challenges that – in our opinion – will be a domain of every human deep-space program.

Multi-Level Challenges in a Long-Term Human Space Program. The Case of Manned Mission to Mars