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Aim: The aim of the study is to investigate the effect of Cynomorium songaricum (CS) on the damage caused by cyclophosphamide (CP) in SD rats. Methods: Rats with CP-induced oligoasthenospermia were treated with different concentration of CS. Testicle weight, epididymal sperm count (ESC), sperm motility, and serum testosterone were analyzed, and expression levels of Thy1, Oct4, PLZF, C-kit, and GDNF were detected in testis tissues. Transmission electron microscopy (TEM) was performed to observe the effect of CS on the spermatogenic damage by CP. Results: Compared with the CP group, there were significant differences in testicle weight, ESC, and sperm motility *Corresponding author: Kun Pang and Conghui Han, Department of Urology, Xuzhou Central Hospital, Jiangsu Xuzhou Jiefang South Road, No. 199, Jiangsu, China. E-mail: pakn1987@163.com # Xiaoxiao Han, Rongsheng Zhou and Wei Zheng contributed equally to this work Research article Unauthentifiziert | Heruntergeladen 29.08.19 17:38 UTC Revista Română de Medicină de Laborator Vol. 27, Nr. 3, Iulie, 2019 292

Cynomorium Songaricum may protect against spermatogenic damage caused by cyclophosphamide in SD rats