English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Objective: The objectives of this study were: determination of serum hepcidin levels in patients with Rheumatoid arthritis (RA) with/without anemia and controls, and its correlation with disease activity and anemia parameters. Patients and Methods: 69 people were involved in our study: 54 patients and 15 healthy subjects (controls). Laboratory evaluation of anemia, iron parameters, serum hepcidin levels and disease activity was carried out. RA patients were divided in two groups: anemic group and non-anemic group (NA), according to hemoglobin levels (Hb). Soluble transferrin receptor-ferritin index (sTfR-F index) was used to classify anemia types: anemia of chronic disease (ACD) and anemia of chronic disease + iron deficiency anemia (ACD+IDA). Disease activity was evaluated using the following parameters: erythrocyte sedimentation rate (ESR), C-reactive protein (CPR), and disease activity score (DAS28). Results: ACD and ACD+IDA groups had significantly higher serum hepcidin concentrations than controls (p<0.001, p<0.001), and NA group (p=0.006, p=0.002). No difference in hepcidin levels was observed between ACD and ADC+IDA groups (p=0.85) and between NA and controls (p=0.66). ESR was significantly higher in ACD and ACD+IDA groups compared with NA group (p<0.001, p=0.002) and controls. (p<0.001, p<0.001).DAS 28 score was higher in anemic groups than NA group (ACD vs. NA, p=0.01), (ACD+IDA vs. NA, p=0.01) and no difference was observed between ACD and ACD+IDA In RA patients serum hepcidin concentration was significantly negatively correlated with hemoglobin (Hb) (r= -0.459, p<0.000) and serum iron( r=-0.357, p<0.01) and positively with disease activity variables: ESR (r=0.352, p<0.01) , CRP (r=0.369, p<0.01), DAS28 score (r=0.289, p<0.05). Conclusion: Hepcidin increases in RA patients with anemia and its levels correlate with Hb, serum iron, and disease activity variables. Rezumat Obiectivul acestui studiu a fost determinarea hepcidinei serice în concordanţa cu profilul anemic la pa- cienţii cu poli artrită reumatoidă (PR) şi evaluarea corelaţiei acesteia cu reactanţii de fază acută (viteza de sedi- mentare a hematiilor (VSH), proteina C reactivă (PCR) şi scorul de activitate al bolii (DAS28). Pacienţi şi meto- de. Profilul anemic, reactanţii de fază acută şi valorile hepcidinei serice au fost determinate la pacienţii cu PR şi pentru lotul martor. DAS2S a fost calculat pentru toţi pacienţii cu PR. Pacienţii cu anemie care au avut valorile sTfR-F index < 1.5 au fost consideraţi ca având anemie cronică secundară bolii(ACD), în timp ce pacienţii care au avut sTfR (receptori solubili de transferina)Aog feritina = (sTfR-F index)< 1.5 au fost clasificaţi ca având anemie cronică secundară bolii cu deficit de fier asociat (ACD+IDA). Rezultate La pacienţii cu PR(n=54), valo- rile hepcidinei serice s-au corelat pozitiv cu reactanţii de fază acută: VSH, (r=0.352, p<0.01), CRP (r=0.369, p<0.01), scorul DAS2S (r=0.289, p<0.05), şi negativ cu hemoglobina (Hb) (r=-0.459, p<0.000) şi cu fierul seric <r=-0.357, p<0.01). Pacienţii cu ACD şi ACD+IDA au prezentat valori semnificativ crescute comparativ cu pa- cienţii din grupul non-anemic şi lotul martor. Nu s-au obsen’at diferenţe semnificativ statistic între grupul ACD şi ACD+IDA. Corelaţii semnificative s-au obsen’at în grupul ACD+IDA între hepcidină şi parametrii caracteris- tici profilului anemic Hb (r= -0.51, p< 0.05), TfS (saturaţiei transferinei) (r= -0.46, p< 0.05) şi fier (r= -0.43, p< 0.05). Concluzii. Hepcidină creşte la pacienţii cu PR şi anemie, iar valorile serice ale acesteia se corelează cu inflamaţia, activitatea bolii precum şi cu Hb şi fierul seric.

Evaluation of serum hepcidin variation in patients with rheumatoid arthritis according to anemia profile and its correlation with disease activity