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Background Effect of isocitr ate dehydrogenase 1 ( IDH1 ) mutation in neovascularization might be linked with tissue perfusion in gliomas. At present, the need of injection of contrast agent and the increasing scanning time limit the application of perfusion techniques. We used a simplified intravoxel incoherent motion (IVIM)-derived perfusion fraction ( SPF ) calculated from diffusion-weighted imaging (DWI) using only three b-values to quantitatively assess  IDH1 -linked tissue perfusion changes in WHO grade II-III gliomas (LGGs). Additionally, by comparing accuracy with dynamic contrast-enhanced (DCE) and full IVIM MRI, we tried to find the optimal imaging markers to predict  IDH1  mutation status. Patients and methods Thirty patients were prospectively examined using DCE and multi-b-value DWI. All parameters were compared between the  IDH1  mutant and wild-type LGGs using the Mann–Whitney U test, including the DCE MRI-derived  K trans ,  v e  and  v p , the conventional apparen t diffusion coefficient ( ADC 0,1000 ), IVIM-de rived perfusion fraction ( f ), diffusion coefficient ( D ) and pseudo-diffusion coefficient ( D* ),  SPF . We evaluated the diagnostic performance by receive r operating characteristic (ROC) analysis. Results Significant differences were detected between WHO grade II-III gliomas for all perfusion and diffusion parameters ( P  &lt; 0.05). When compared to  IDH1  mutant LGGs,  IDH1  wild-type LGGs exhibited significantly higher perfusion metrics ( P  &lt; 0.05) and lower diffusion metrics ( P  &lt; 0.05). Among all parameters,  SPF  showed a higher diagnostic performance (area under the curve 0.861), with 94.4% sensitivity and 75% specificity. Conclusions DWI, DCE and IVIM MRI may noninvasively help discriminate  IDH1  mutation statuses in LGGs. Specifically, simplified DWI-derived  SPF  showed a superior diagnostic performance.

radiology and oncology

Simplified perfusion fraction from diffusion-weighted imaging in preoperative prediction of <i>IDH1</i> mutation in WHO grade II–III gliomas: comparison with dynamic contrast-enhanced and intravoxel incoherent motion MRI

Simplified perfusion fraction from diffusion-weighted imaging in preoperative prediction of IDH1 mutation in WHO grade II–III gliomas: comparison with dynamic contrast-enhanced and intravoxel incoherent motion MRI