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Portal vein thrombosis (PVT) in cirrhosis is a relatively frequent complication with a 5-year cumulative incidence of 10.7%[1] to 20%.[2] In contrast to non-cirrhotic PVT, which is almost always caused by a thrombophilic factor, cirrhotic PVT is related to a decelerated blood flow through the portal vein and the presence of a thrombophilic factor is an exception.[1,3-5] In addition, advanced disease and large varices with a high flow are related to PVT.[1,2] The varices may further reduce the portal vein flow velocity and cause turbulent flow at the junction with the portal or splenic vein.

Timing of the treatment of portal vein thrombosis in patients with cirrhosis: A German hepatologist’s perspective