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Summary Introduction:  There are many scientific reports on the beneficial effects of epigallocatechin gallate and resveratrol on the human body, e.g. antioxidant properties, a protective effect on the circulatory system and reduction of inflammation. Objective:  The aim of the study was to evaluate the effect of these substances on the survival of mesenchymal stem cells (MSC) in the presence of the pro-apoptotic factor staurosporine. Methods:  Cell viability WST-1 colorimetric assay. Results:  It was confirmed that both 25  µ M/ml and 50  µ M/ml of epigallocatechin and 50  µ M/ml of resveratrol statistically significantly increased the MSC survival rate. Conclusion:  An excess supply of epigallocatechin gallate (50  µ M/ml and higher) has a cytotoxic effect on MSC, which may have a negative impact on the body’s auto-regenerative capacity. Under toxic and stressful conditions, resveratrol and epigallocatechin gallate perform cytoprotective functions, thereby reducing the negative impact of toxic environmental conditions on the mesenchymal stem cells.

Cytoprotective roles of epigallocatechin gallate and resveratrol on staurosporine-treated mesenchymal stem cells in in vitro culture