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Summary Introduction:  Psoriasis is an inflammatory skin disease characterized by hyper-proliferation, abnormal epidermal keratinocytes and inflammatory infiltration. It affects approximately 4% of the population globally. Herbal extracts have better results with less toxic effects than the synthetic drugs in the treatment of psoriasis. Objective:  Present study was aimed to access the anti-psoriatic effect of andrographolide extracted from  Andrographis paniculate  ( A. paniculata ). Method:  We extracted, characterized, and screened the extracted andrographolide for anti-proliferative characteristics using cultured cell model of human HaCaT keratinocyte. Results:  Andrographolide at 31.25  µ g/mL (90  µ M) demonstrated significant inhibitory effect on human HaCaT keratinocytes proliferation in cell culture. To our best knowledge, we reported the anti-proliferative potency of andrographolide extracted from  A. paniculata  for the first time. Conclusion:  The results suggest that the andrographolide extracted from  A. paniculata  plant may have potential to be used in the management of psoriasis.

herba polonica

Isolation, characterization and evaluation of anti-proliferative properties of andrographolide isolated from <i>Andrographis paniculata</i> on cultured HaCaT cells

Isolation, characterization and evaluation of anti-proliferative properties of andrographolide isolated from Andrographis paniculata on cultured HaCaT cells