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A potential protective effect of probiotic strains against zoonotic Trichinella spiralis infection was investigated in the framework of a new therapeutic strategy aimed at using probiotics to control parasitic zoonoses. The study was focused on the impact of six selected probiotic (bacteriocinogenic) strains on the intensity of T . spiralis infection and female fecundity ex vivo and in vitro . Bacterial strains of different origin ( Enterococcus faecium EF55, Enterococcus faecium 2019 = CCM7420, Enterococcus faecium AL41 = CCM8558, Enterococcus durans ED26E/7, Lactobacillus fermentum AD1 = CCM7421, Lactobacillus plantarum 17L/1) were administered daily in a dose of 10 9 CFU/ml in 100 μl, and mice were infected with 400 T . spiralis larvae on day 7 of treatment. Female adults of T . spiralis were isolated on day 5 post infection (p.i.) and subsequently were used in fecundity test ex vivo . E . faecium CCM8558, E . faecium CCM7420 and E . durans ED26E/7 strains significantly reduced the number of adults in the intestine. The application of L . fermentum CCM7421, L . plantarum 17L/1, E . faecium CCM8558 and E . durans ED26E/7 caused a significant decrease in the number of muscle larvae. The treatment with E . faecium CCM8558 and E . durans ED26E/7 showed the highest inhibitory effect on female fecundity (94 %). The number of newborn larvae (NBL) was also significantly decreased after administration of L . fermentum CCM7421 and L . plantarum 17L/1 (80 %). A direct impact of probiotic strains on female reproductive capacity was examined in vitro in females isolated from untreated infected mice on day 5 p.i. A correlation was found between the inhibitory effect and the concentration of probiotic strains. The reduction effects of the strains manifested as follows: L . fermentum CCM7421 (93 %), E . faecium CCM8558, L . plantarum 17L/1, E . faecium EF55 (about 80 %), E . faecium CCM7420 and E . durans ED26E/7 (about 60 %).

The anti-parasitic effect of probiotic bacteria via limiting the fecundity of Trichinella spiralis female adults