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It has been suggested that ammonium compounds in tobacco generate nitrogen monoxide (NO) in cigarette smoke. This causes the smoke to retain the broncho-dilatory properties of the tobacco, which leads to an increased uptake of nicotine and thus to a potentially higher addiction to tobacco. The objective of this study was to ascertain putative correlations among the concentration of ammonium compounds in whole tobacco and the concentration of NO in mainstream smoke

contributions to tobacco and nicotine research

The Relation Between the Quantity of Ammonium Compounds in Tobacco and the Nitrogen Monoxide (NO) Levels in the Smoke of Cigarettes Marketed in the Netherlands