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Genetic and epigenetic factors have an important role during the development of osteoporosis. Receptor activator of nuclear factor-κ B (NF-κB) (RANK)/receptor activator of NF-κB ligand (RANKL) pathway is important for the bone remodeling, and NFATC1 and FOS are the downtargets of this pathway. Here, we report methylation status of  NFATC1  and  FOS  genes in post- and premenopausal women. In this study, 30 premenopausal and 35 postmenopausal women were included. Methylation sensitive-high resolution melting (MS-HRM) analysis was used for identification of  NFATC1  and  FOS  genes methylation. The  NFATC1  gene was methylated in 11 of the 35 postmenopausal women, and the  FOS  gene was methylated in six of the postmenopausal women ( p  &gt;0.005). Here, we found statistically significant association between unmethylation of the  NFATC1  gene and postmenopausal status. This result explains the epigenetic regulation of osteoclasts during the menopausal transition, and for the first time, our results can be used for epigenetic explanation of postmenopausal osteoporosis in the literature. However, the limited number of studies in this field makes our results crucial. Our results showed great value of epigenetic profiles of postmenopausal women.

Do we use methylation of NFATC1 and FOS genes as a biomarker for postmenopausal osteoporosis?