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This study monitors the effect of male smoking and age of the woman on the success of the intracytoplasmic sperm injection (ICSI) fertilization process as part of the assisted reproduction technique (ART). A total of 703 couples in the  in vitro  fertilization (IVF) program were included. Binary logistic regression analysis was used to study the effect of male smoking on clinical pregnancy rate and live birth rate. The results from the study showed that interaction of male smoking and women’s age (&gt;35 years) have significant negative impact on ongoing pregnancy rate and live birth rate.

The interaction of female age and active male smoking has negative influence on success rates of the in vitro fertilization treatments