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The present experiment aimed to evaluate the partial replacement of soybean with slow-release urea (Optigen 1200™) in the diet of lactating cows for 84 d. Three-hundred multiparous lactating Holstein (635 ± 25 kg of body weight, BW) cows were stratified by live body weight; parity and previous milk production were randomly assigned into two experimental groups with 150 cows per each treatment. In the control treatment, 25 g soybean meal was replaced by 5.7 g slow-release urea for 84 d. Optigen treatment did not affect feed intake, daily milk production, milk composition, or milk (feed) efficiency; however, increased (P&lt;0.01) total BW gain and daily BW gain. Optigen treatment increased (P&lt;0.01) the digestibility of crude protein and neutral detergent fiber. Optigen treatment increased (P&lt;0.01) estimated N balance, milk urea-N, and net energy (NE) for gain. Without affecting blood total protein, creatinine, urea-N, triglycerides, glucose, β-hydroxybutyrate, or non-esterified free fatty acids, Optigen treatment increased the concentrations of blood albumin and cholesterol compared to the control (P&lt;0.05). In conclusion, slow-release urea could replace soybean meal in ruminant diets with no adverse effects on feed intake, nitrogen utilization, or digestibility; however, improve the total tract digestibility of fiber and crude protein in cows.

annals of animal science

Slow-release urea partially replacing soybean in the diet of Holstein dairy cows: intake, blood parameters, nutrients digestibility, energy utilization, and milk production