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The aim of this study was to define the transcript expression of 12 genes, identify new polymorphisms in selected 2 genes and to estimate the association between the level of expression, gene polymorphism and litter size in sows. Two groups of sows were selected: 71 crossbred sows and 328 purebred sows. For transcript analysis endometrial tissue samples were collected, while blood was sampled for the purpose of DNA polymorphism analysis. For all animals data on litter size and weaned piglets were obtained. Transcript analysis of 12 genes was performed in the uterine endometrium of sows in the luteal and follicular phases. Eight out of 12 genes showed higher mRNA expression levels during the luteal phase ( AREG ,  FABP3 ,  IL1A ,  ITGAV ,  ITGB3 ,  NMB ,  OPN ,  RBP4 ). In turn, higher expression levels in the follicular phase were observed for 4 genes ( IL1B ,  PPARG ,  S100A8 ,  SELL ). Analysis of six new polymorphic sites within the  OPN  and  AREG  genes revealed the highest heterozygosity for OPNe6_Knoll, OPNp3_617 and AREGe2_317 polymorphisms and the lowest heterozygosity in the AREGe3_561 locus. Association analyses concerning transcript expression levels of the 12 genes and the  OPN  and  AREG  genotypes in the two groups of sows showed a significant relationship between the  IL1A ,  ITGB3  transcript expression and the OPNe7_603 genotype also between OPNp3_617 genotype and  ITGB3  transcript expression. With regard to the litter size and the number of weaned piglets a significant relation with the OPNp3_617, OPNe6_462 and AREGe2_317 genotypes was observed only in the purebred sows. Transcript expression of the genes encoding osteopontin and amphiregulin in the uterus of the sows affect reproductive traits by preparing the uterus for embryo reception.

annals of animal science

Polymorphism of <i>OPN</i> and <i>AREG</i> Genes in Relation to Transcript Expression of a Panel of 12 Genes Controlling Reproduction Processes and Litter Size in Pigs

Polymorphism of OPN and AREG Genes in Relation to Transcript Expression of a Panel of 12 Genes Controlling Reproduction Processes and Litter Size in Pigs