English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

This study determined the influence of photoperiod on the expression of toll-like receptor 2 and 4 ( TLR2  and  TLR4 ), interleukin 1□ ( IL1B ), IL-1 receptor type I ( IL1R1 ) and II ( IL1R2 ), interleukin 6 ( IL6 ), the IL-6 receptor ( IL6R ) and signal transducer ( IL6ST ), tumor necrosis factor α ( TNF ), and TNF□ receptor type I ( TNFRSF1A ) and II ( TNFRSF1B ) in the choroid plexus (ChP) of ewes with lipopolysaccharide (LPS)-induced acute inflammation. Under short-days (SD, n = 12, anestrous) and long-days (LD, n = 12, synchronized follicular phase), ewes were treated with saline or LPS. Compared to LD conditions, the ewes under SD were characterized by a greater (P&lt;0.05) area under the curve (AUC) of cortisol in the LPS-treated group and by a lower (P&lt;0.05) AUC of prolactin in the saline-treated group. Under both photoperiods, LPS increased (P&lt;0.05) the expression of all examined genes except for  TNFRSF1B  (only under SD),  TNF  and  TNFRSF1A  (no stimulation), and  IL6R  (decreased (P&lt;0.05) under SD). The LPS-induced increases in  TLR2 ,  TLR4 ,  IL1B  and its receptors,  IL6  and  TNFRSF1B  were higher (P&lt;0.05) under SD than LD.  TLR4  was positively correlated with  IL1B  and  IL6  in both saline- (r 2  = 0.64, P&lt;0.01 and r 2  = 0.52, P&lt;0.01) and LPS-treated (r 2  = 0.81, P&lt;0.0001 and r 2  = 0.51, P&lt;0.001) ewes.  IL1B  (r 2  = 0.56, P&lt;0.01 and r 2  = 0.77, P&lt;0.0001) and  IL6  (r 2  = 0.77, P&lt;0.005 and r 2  = 0.35, P&lt;0.05) were positively correlated with  TLR2  in saline- and LPS-treated ewes, respectively. This indicates that in ewes, the ChP response to acute systemic inflammation is dependent upon the photoperiod with stronger effects being observed under SD. Our results also suggest that gonadal hormones altering TLR4 signaling events are involved in the photoperiodic modulation of the ChP response to LPS. Further experiments are required to explain the mechanism involved in this phenomenon.

Photoperiod alters the choroid plexus response to LPS-induced acute inflammation in EWES