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The aim of this paper is the study of physico-chemical properties of the chosen compounds, derivatives of 2-hydroxy-3-[2-(4-methoxyphenyl)ethylamino]propyl-4-[(alkoxycarbonyl)amino]benzoates and 2-hydroxy-3-[2-(2-methoxyphenyl)ethylamino]propyl-4-[(alkoxycarbonyl)amino]benzoates with potential ultra-short beta-adrenolytic activity. The studied compounds are different in theposition of the substituent on the benzene ring in the side chain as well as in the aromatic ring in position 4 with alkyl- (methyltobutyl-) carbamate. The physico-chemical characteristics, for example, lipophilicity, surface activity, adsorbability, acidobasicproperties etc., are very important for the explanation of the relationship between structure and biological activity of the drug.These parameters serve as the base of quantitative structure-activity study. The goal of this work is to establish the spectral characteristicsof studied compounds in UV-area, pKa values, the parameters of lipophilicity (the values of Rf and RM from thin layerchromatography, retention time t´R and capacity factor k´ from liquid chromatography and experimental partition coefficientslog P´ values), surface tension, critical micelle concentrations, the adsorbability of compounds expressed by percent of adsorbedcompound on active charcoal β% as well as by Freundlich adsorption isotherms. The obtained values are correlated with theparameters characterising the size of molecule, for example, the number of carbon atoms on carbamate functional group

Study of physico-chemical properties of potential beta-adrenolytics