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The mammalian zona pellucida (ZP) is an extracellular matrix that surrounds immature and mature oocytes and early embryos until the stage of a blastocyst and its implantation. This mini-review summarizes basic information on the ZP and its morphologic and functional changes during  in vitro  oocyte maturation and fertilization and  in vivo  pre-implantation embryo development.

Changes of the zona pellucida patterns during oocyte maturation, fertilization and embryo development in mammals: mini-review