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Resistance to chemotherapy is the main obstacle in contemporary ovarian cancer treatment. The aim of this study was the evaluation of expression of  HERC5 ,  IFIH1 ,  SAMD4 ,  MCTP1  and  SEMA3A  mRNA and assessment their role in resistance to cisplatin, paclitaxel, doxorubicin and topotecan in seven ovarian cancer cell lines. MTT assay was used in resistance assessment. Quantitative polymerase chain reaction was performed to measure the expression levels of the genes. We observed different levels of resistance among cell lines. The resistance was not related to the expression of drug transporters genes. The expression of  HERC5  and  IFIH1  genes was upregulated, and the expression of  SEMA3A  gene was downregulated. Expression of  SAMD4  was upregulated in PEA1, PEA2, and PEO23 cell lines, and expression of  MCTP1  was downregulated in A2780, PEA2, and PEO23 cell lines. Upregulation of  HERC5 ,  IFIH1 , and  SAMD4  and downregulation of  SEMA3A  and  MCTP1  in TOP-resistant ovarian cancer cell lines may suggest some role of those genes in topotecan resistance development.

The significance of HERC5, IFIH1, SAMD4, SEMA3A and MCTP1 genes expression in resistance to cytotoxic drugs in ovarian cancer cell lines