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Background Adenosine monophosphate (AMP)-activated protein kinase (AMPK; EC 2.7.11.31) enzymes play a pivotal role in cell metabolism. They are involved in type 2 diabetes mellitus (T2DM) pathogenesis. Genetic variation of  PRKAA2  coding for the AMPK α2 catalytic subunit (AMPKα2) is reported to be associated with susceptibility for T2DM. Objectives To determine the association between  PRKAA2  genetic variations (rs2796498, rs9803799, and rs2746342) with clinical characteristics in patients newly diagnosed with T2DM. Methods We performed a cross-sectional study including 166 T2DM patients from 10 primary health care centers in Yogyakarta, Indonesia. We measured fasting plasma glucose, hemoglobin A1c, serum creatinine, glomerular filtration rate, blood pressure, and body mass index as clinical characteristics.  PRKAA2  genetic variations were determined by TaqMan SNP genotyping assay. Hardy–Weinberg equilibrium was calculated using χ 2  tests. Results There was no difference in clinical characteristics for genotypes rs2796498, rs9803799, or rs2746342 ( P  &gt; 0.05). No significant association was found between  PRKAA2  genetic variations and any clinical feature observed. Further subgroup analysis adjusting for age, sex, and waist circumference did not detect any significant association of  PRKAA2  genetic variations with clinical characteristics ( P  &gt; 0.05). Conclusion PRKAA2  genetic variation is not associated with the clinical characteristics of Indonesian patients with newly diagnosed T2DM.

PRKAA2variation and the clinical characteristics of patients newly diagnosed with type 2 diabetes mellitus in Yogyakarta, Indonesia