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Background: Exercise has various effects on hepatic and pancreatic function. There is little information available for effects of exercise on histopathological changes in the liver and pancreas. Objective: Investigate the effect of intensive exercise on blood biochemical changes and histopathology in rat liver and pancreas. Materials and methods: Male Sprague-Dawley rats were randomly divided into five groups: 1 (normal control): no exercise, 2 (exercise 75% VO2max): running on treadmill at 75% VO2max and sacrificed immediately after exercise, 3 (exercise 75% VO2max+6 hours): running on treadmill at 75% VO2max and sacrificed at six hours after exercise, 4 (exercise 90% VO2max): running on treadmill at 90% VO2max and immediately sacrificed after exercise, 5 (exercise 90% VO2max+6 hours): running on treadmill at 90% VO2max and sacrificed at six hours after exercise. Samples of blood, liver and pancreas were collected at the end of each experiment. Results: The levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) increased significantly in group 2 and 4, compared with normal control. Serum total bilirubin (TB) and enzyme lipase increased significantly in group 4 compared with normal control. In all group of exercise, liver histopathology showed hepatocyte edema and necroinflammation, and pancreas showed congestion and edema. Conclusion: High-intensity exercise at 75% and 90% VO2max caused an increase of biochemical parametes in liver and pancreas. The levels of exercise also caused histopathology changes in the liver and pancreas.

Effects of intense exercise on biochemical and histological changes in rat liver and pancreas