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Clearance of airway secretion is one of the most important problems in the patients with chronic airway diseases.We deviced a new method assisting clearance of airway secretion, and evaluated the validity of the method experimentally and clinically.In experimental studies, the resonance frequency of sputum was sought with Matsudaira's vibrator and the mucociliary transport rate of sputum plugged in dissected chicken trachea was measured, with and without administration of oscillatory pressure at near the resonance frequency.In clinical study, 15 patients with chronic pulmonary disease were applied oscillatory pressure via mouthpiece during respiration and sputum volume, VC, FEV1.0 and blood gas were examined.The results were as follows.1. The resonance frequencies of most sputa were less than 10Hz.2. In the experiment with chicken trachea, oscillation (via the airway) at near the resonance frequency of human sputa enhanced the movement of impacked human sputum toward the oral site, which increased with declivity of the trachea.3. This phenomenon was not observed in the trachea whose activity of mucociliary transport had been lost.4. This method was applied for 15 patients together with postural drainage. In 14 patients, volume of expectrated sputum increased, but no remarkable changes were found in the clinical examination data, lung function test or blood gas analysis.

Enhancement of MCT by Oscillation of Mucus Plug and Its Clinical Application to Assisting Clearance of Airway Secretion