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We evaluated the feasibility of prenatal quantification of liver and spleen iron by magnetic resonance imaging (MRI) gradient recalled echo (GRE) measurements of transverse relaxation time (R2*) (MRI-GRE-R2*) in a fetal sheep model and applied the method to a human neonate with suspected neonatal hemochromatosis.

magnetic resonance in medical sciences

Quantification of Prenatal Liver and Spleen Iron in a Sheep Model and Assessment of Iron Stores in a Human Neonate with Neonatal Hemochromatosis using R2* Mapping