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methotrexate (MTX)   (acute lymphoblastic leukemia, ALL)   (non-Hodgkin lymphoma, NHL)   . MTX  2.5 mg 12 g/m       ,  1 g/m    MTX  .  MTX   , , ,   ,     ,           . MTX dihydrofolate reductase (DHFR)    dihydrofolates (FH2)    tetrahydrofolate (FH4)      . Leucovorin folic acid   leucovorin    MTX  FH4    ,  MTX       MTX   leucovorin .       hydration leucovorin      MTX      . ALL  NHL   MTX 5 g/m 24 ABSTRACT

Delayed Elimination After High-dose Methotrexate in Pediatric Patients with Acute Lymphoblastic Leukemia and Non-Hodgkin Lymphoma