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Background and Objective: Severe traumatic brain injury (TBI) is one of the major cause of morbidity and mortality in trauma. Circulating interleukin-6 (IL-6) and neuroprotection from temperature has a strong relation with improve outcome. The aim of this study is to evaluate the brain protection properties of intravenous metamizole as a hypothermic pharmacologic in reducting IL-6 and core temperature regulation on severe TBI. Subject and Method: This is a randomized controlled trial to 30 adult pasien with severe TBI which was distributed into two groups which was control group (K) and metamizole group(M). The M grup was given 15 mg/kgbw of intravenous metamizole every 8 hours for 72 hours. Core temperature from the tympnic membrane every 8 hours and IL-6 every 24 hours was noted for 72 hours. This studi was conducted from July to August 2016 and the data was then analyzed statistically using the paire t test, Mann-Whitney test, Chi-Square test and Fishers’s Exact test. Result: Shows that IL-6 on the M group was 244.20±93.07 which was lower than the K group at 375.20±152.62 with p=0.006 on the 48th hour and on the 72nd hour with IL-6 at 197.20±76.03 with p=0.008 which is statistically significant (p<0.005) and also shows lower temperature at every recording with p<0.01. Conclusion: Metamizole has brain protecting properties in reducing circulating IL-6 and has uses as a hypothermic agent in severe TBI.

Insidensi Hipoksemia dan Hipotensi pada Cedera Otak Traumatik di RSUP Dr. Hasan Sadikin Bandung Tahun 2015