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Garlic is often used by people to treat various diseases, especially bacterial infection disease. Garlic (Allium sativum) contains palmitic acid, which is assumed to have the antibacterial activity against Streptococcus mutans through bacterial cytoplasmic membrane lysis and inhibits the activity of bacterial enzymes. The purpose of this study was to determine the antibacterial activity of garlic (Allium sativum) palmitic acid on the growth of Streptococcus mutans ATCC 25175. Methods: This research was descriptive. Purity analysis of the isolated compound of palmitic acid was performed using a thin layer chromatography (TLC). The inhibition zone test of Streptococcus mutans was carried out afterwards, using the Kirby-Bauer diffusion method on the Mueller Hinton agar medium. The research control was chlorhexidine. A calliper measured the inhibition zone formed around the paper disk. Results: The TLC results showed that the isolated active compound was palmitic acid. Garlic palmitic acid in the concentrations of 0.5%, 2%, 4%, 8%, and 12% did not have inhibitory zone towards Streptococcus mutans and showed white lumps of fatty acids around the paper disk. Chlorhexidine showed an inhibition zone with an average of 18 mm. Conclusion: Garlic (Allium sativum) palmitic acid has no antibacterial activity towards Streptococcus mutans ATCC 25175.

padjadjaran journal of dental researchers and students

&lt;p&gt;Daya antibakteri asam palmitat bawang putih (Allium sativum) terhadap Streptococcus mutans ATCC 25175&lt;/p&gt;&lt;p&gt;Antibacterial activity of garlic (Allium sativum) palmitic acid towards Streptococcus mutans ATCC 25175&lt;/p&gt;