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Microbes and plants are sources of secondary metabolites that potential and actively explored. The Laboratory of Enzyme, Fermentation and Biomolecular of the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Riau University has isolated several types of microbes, especially fungi from peat soil, Primary Forest Biosphere Reserve Giam Siak Kecil Bukit Batu (GSKBB) Riau Province. Some of these isolates were the fungi Penicillium sp. LBKURCC29 and LBKURCC30 which have the potential to produce cellulase. The purpose of this study was to explore the another potential of the two Riau peat soil locat isolates, in this case the potential as a source of antimicrobial and anti-fungal Candida albicans. The production of secondary metabolites that are potential as antifungi was done by fermentation in a liquid medium inoculated with spores of Penicillium sp. LBKURCC29 or LBKURCC30 (7×10 12 spores in 50 mL of media) for 14 days in rotary shaker then filtered with filter paper GF/C. The filtrate was extracted using ethyl acetate. The ethyl acetate crude extracts was evaporated using rotary evaporator. The crude extract dissolved with metanol. In this study, extract characterization was applied by phytochemical test, TLC and HPLC. Antimicrobial test was performed by the disc diffusion method toward pathogen fungi C. albicans. The result of phytochemicals test showed that each extract of Penicillium sp. LBKURCC29 dan LBKURCC30 were positive for terpenoid. Further characterization revealed that the patterns of TLC and HPLC chromatograms were different. The activity to C. albicans showed only extract of Penicillium sp. LBKURCC29 has activity on concentration 5,7 mg/mL that showed clear zone of inhibition, approximately 8,05 mm equal to 33,78% inhibitions compared to Ketokonazol ® inhibition (23,83 mm).

Metabolit Sekunder Sekresi Jamur Penicillium spp. Isolat Tanah Gambut Riau sebagai Antijamur Candida albicans