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In this paper, the simultaneous quantitative assay of Fluocortolone caproate (FCC), Fluocortolone pivalate (FCP) and Cinchocaine HCl (CIN) in suppository has been reported as a simple alternative analytical method. A partial least squares (PLS-2) regression was used for resolution of the overlapped spectrophotometric signals from mixtures of the three drugs. A calibration set containing FCC, FCP and CIN was constructed by using 33 full factorial design in the concentration range of 4.5-8.5, 5-7 and 8-12 μg/mL, respectively. Absorption spectra were recorded in the range 240-350 nm. To check the quality of the proposed method, it was applied to the determination of these compounds in synthetic mixtures and pharmaceutical formulation, suppository. The PLS-2 method yielded recoveries ranging from 91 to 106%. The results compared well with those from the reported HPLC method.

Multivariate calibration method for Simultaneous estimation of Fluocortolone caproate, Fluocortolone pivalate and Cinchocaine HCl in suppository