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It is well known that long term administration of high dose loop diuretics in patients with heart failure, may in some cases aggravate the cardiac failure symptoms. Part of this effect may be due to thiamine depletion secondary to diuretics use. The aim of our present study was to assess whether administration of benfothiamine in patients with advanced congestive cardiac failure treated on long term with high dose loop diuretics, can prevent the alteration of heart failure.

Benfothiamine Administration in Patients with Dilated Cardiomyopathy and Advanced Heart Failure with Chronic Diuretic Treatment