English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Issledovanie mekhanizmov regeneracii pri ranevom processe i poisk novyh putej povysheniya effektivnosti zazhivleniya yavlyayutsya odnimi iz aktual'nyh napravlenij v medicine. Poetomu predstavlyaetsya celesoobraznym izuchenie reparativnyh effektov regulyatornyh peptidov, obladayushchih fiziologicheskoj polifunkcional'nost'yu i okazyvayushchih vliyanie na processy rosta i differencirovki kletok. Cel'yu issledovaniya bylo izuchit' vliyanie peptidov Gly-His-Lys (GHK) i Gly-His-Lys-D-Ala (GHK-D-Ala) na processy regeneracii v usloviyah inficirovannoj kozhnoj rany u krys. Ranu modelirovali na 150 zhivotnyh putem naneseniya na uchastke spiny polnoslojnoj rany, peptidy vvodili v dozah 0,5 i 1,5 mkg/kg podkozhno v oblasti rany raz v den'  v techenie 3, 7 ili 10 sutok. Dlya ocenki techeniya ranevogo processa  izuchali gistologicheskie i morfologicheskie preparaty uchastkov rany s prilezhashchej intaktnoj kozhej. GHK-D-Ala v doze 0,5 mkg/kg okazyval bolee vyrazhennoe, chem GHK, vliyanie na regenerativnye processy v rane, chto otrazilos' v znachimom snizhenii chisla granulocitov i limfocitov i povyshenii chisla kletok fibroblasticheskogo ryada, makrofagov i kletochnogo indeksa po sravneniyu kak s kontrol'noj gruppoj (p &lt; 0,05–0,001), tak i s zhivotnymi, kotorym vvodili GHK v ekvivaletnoj doze (p &lt; 0,05–0,001). Pri uvelichenii dozy do 1,5 mkg/kg effekty GHK-D-Ala neskol'ko oslabevali. Po rezul'tatam sravneniya issledovannyh pokazatelej naibol'shaya aktivaciya regerativnyh processov v rane vyyavlena posle vvedeniya GHK-D-Ala v doze 0,5 mkg/kg. Takim obrazom, prisoedinenie D-alanina k S-koncu peptida GHK sposobstvovalo oslableniyu vospal'noj reakcii i usileniyu regenerativnyh processov pri mestnom vvedenii v usloviyah inficirovannoj kozhnoj rany.

Regenerativnye effekty peptidov Gly-His-Lys i Gly-His-Lys-D-Ala pri kozhnoj inficirovannoj rane