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Formirovanie i podderzhanie immuniteta protiv SARS-CoV-2 yavlyaetsya vazhnym usloviem preodoleniya pandemii novoj koronavirusnoj infekcii COVID-19. Cel'yu raboty bylo oharakterizovat' dinamiku urovnya antitel IgG k receptor-svyazyvayushchemu domenu (RBD) SARS-CoV-2 s ispol'zovaniem nabora dlya immunofermentnogo analiza (IFA), otkalibrovannogo pri pomoshchi Mezhdunarodnogo standarta anti-SARS-CoV-2-immunoglobulinov (ISSARS-CoV-2). Koncentraciyu anti-RBD-IgG izmeryali v kogorte lic posle vyzdorovleniya ot COVID-19 s intervalom v mesyac v techenie 6 mesyacev i v tochke 12 mesyacev s ispol'zovaniem naborov IFA, otkalibrovannyh IS-SARS-CoV-2; rezul'taty predstavlyali v edinicah svyazyvaniya antitel (BAU) na 1 ml. Vsego issledovali 97 obrazcov syvorotki krovi ot 20 chelovek s PCR-podtverzhdennoj infekciej SARS-CoV-2. K pervomu mesyacu posle zarazheniya srednij geometricheskij titr (GMT) anti-RBD-IgG sostavil 433 BAU/ml (diapazon 36–25900 BAU/ml). So vremenem koncentraciya IgG protiv RBD postepenno snizhalas', dostigaya GMT v 68 BAU/ml k 12 mesyacu; anti-RBD-IgG sohranyalis' u 13 iz 14 (93%) lic, obsledovannyh cherez 12 mesyacev posle inificirovaniya. Standartizirovannye kolichestvennye serologicheskie dannye igrayut vazhnuyu rol' v monitoringe immunnogo otveta i oblegchayut sravnenie mezhdu issledovaniyami, sozdavaya osnovu dlya poiska obshchego serologicheskogo korrelyata immunnoj zashchity protiv SARS-CoV-2.

Dinamika koncentracii antitel k SARS-CoV-2 v techenie 12 mesyacev posle perenesennoj infekcii COVID-19