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Differencial'naya diagnostika bolezni Parkinsona i fenotipicheski skhozhego dvigatel'nogo rasstrojstva — essencial'nogo tremora, osobenno v debyute zabolevaniya, ostaetsya odnoj iz nereshennyh zadach sovremennoj nevrologii. Cel'yu issledovaniya bylo ocenit' diagnosticheskuyu znachimost' vizualizacii nigrosom — klasterov dofaminergicheskih nejronov v chernoj substancii (CHS) srednego mozga, vyyavlyaemyh pri ispol'zovanii SWIrezhima vysokorazreshayushchej magnitno-rezonansnoj tomografii (3 Tesla), u 20 pacientov s bolezn'yu Parkinsona i u 10 pacientov s essencial'nym tremorom. Vizual'nyj analiz izobrazhenij nigrosomy-1 provodili s ispol'zovaniem chetyrekhchlennoj poryadkovoj shkaly. Razlichiya po gendernomu, vozrastnomu sostavu i prodolzhitel'nosti zabolevaniya rasschityvali s pomoshch'yu tochnogo kriteriya Fishera, U-kriteriya Manna–Uitni. Dlya rascheta diagnosticheskoj cennosti dannoj metodiki ispol'zovali kriterij χ2 Pirsona. U pacientov s bolezn'yu Parkinsona v 70% sluchaev nablyudali odno- ili dvustoronnee ischeznovenie nigrosomy-1. Eshche u dvuh pacientov s bolezn'yu Parkinsona (10%) vyyavili menee specifichnye izmeneniya chernoj substancii — umen'shenie ob"ema nigrosomy-1. Naprotiv, u vsekh pacientov s essencial'nym tremorom (100%) nigrosoma-1 ostavalas' sohrannoj s dvuh storon (p &lt; 0,001). Poluchennye predvaritel'nye rezul'taty demonstriruyut vysokij potencial metodiki vizual'nogo analiza nigrosomy-1 v differencial'noj diagnostike bolezni Parkinsona i essencial'nogo tremora.

Vizual'nyj analiz nigrosomy-1 v differencial'noj diagnostike bolezni Parkinsona i essencial'nogo tremora