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Adenokarcinoma pishchevoda razvivaetsya, kak pravilo, v nizhnej chasti organa. Prodolzhitel'nost' zhizni i vyzhivaemost' pri dannom zabolevanii zavisyat ot stadii patologicheskogo processa i sostoyaniya zdorov'ya pacienta. Naibolee uspeshnyj metod dlya lecheniya adenokarcinomy pishchevoda — himioluchevaya terapiya. Problema podbora optimal'nyh doz oblucheniya dlya polucheniya maksimal'nogo effekta po sej den' aktual'na. Cel'yu issledovaniya bylo izuchit' effektivnye dozy i ocenit' protivoopuholevuyu aktivnost' luchevoj terapii na ortotopicheskom PDX adenokarcinomy pishchevoda cheloveka. Issledovanie proveli na samkah myshej linii Balb/c nude (n = 25). Ortotopicheskuyu transplantaciyu osushchestvlyali putem implantacii obrazcov opuholi pacienta v shejnyj otdel pishchevoda immunodeficitnoj myshi. Luchevoe vozdejstvie na ortotopicheskie ksenografty issledovali v 3 etapa s kratnost'yu oblucheniya 1 raz v dozah 4, 6, 8 i 10 Gr. Po rezul'tatam gistologicheskogo analiza ksenografty 1-j generacii vosproizvodili osnovnye morfologicheskie harakteristiki opuholi pacienta. Ocenka dinamiki rosta ob"emov opuholevyh uzlov eksperimental'nyh zhivotnyh pozvolyaet sdelat' vyvod, chto u zhivotnyh, obluchennyh v odnokratnoj doze 6, 8 ili 10 Gr, srednie znacheniya ob"emov opuholevyh uzlov statisticheski znachimo otlichalis' (r ≤ 0,01) ot znachenij v kontrol'noj gruppe posle kazhdoj iz trekh procedur luchevogo vozdejstviya. Po raschetam pokazatelya tormozheniya rosta opuholi pri summarnoj doze 18 Gr nablyudali znachitel'noe podavlenie rosta opuholi. Dal'nejshee povyshenie dozy luchevogo vozdejstviya bylo neeffektivno. Ustanovili, chto snizhenie ob"emov opuholevyh uzlov v ksenograftah korreliruet s uvelicheniem razovoj dozy, pri etom summarnaya doza bolee 18 Gr pagubno vliyaet na sistemu krovetvoreniya i biohimicheskie pokazateli krovi myshej.

Protivoopuholevoe vliyanie luchevoj terapii na ortotopicheskuyu PDX-model' adenokarcinomy pishchevoda cheloveka