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Razrabotka i patogeneticheskoe obosnovanie primeneniya novyh sredstv dlya lokal'noj terapii termicheskoj travmy (TT) — odna iz aktual'nyh problem mediciny. Melatonin (MT) — endogennyj faktor regulyacii gomeostaza s plejotropnym potencialom. Cel'yu raboty bylo ocenit' pokazateli reparacii, funkcional'noe sostoyanie tuchnyh kletok (TK), soderzhanie matriksnoj metalloproteinazy-9 (MMP-9) i faktora rosta sosudistogo endoteliya (VEGF) v ochage povrezhdeniya kozhi v dinamike eksperimental'noj TT v usloviyah primeneniya original'noj dermal'noj plenki (DP) s MT. TT stepeni IIIA ploshchad'yu 3,5% modelirovali pogruzheniem uchastka kozhi v kipyashchuyu vodu. DP ploshchad'yu 12 sm2 s MT v koncentracii 5 mg/g nanosili ezhednevno v techenie pyati sutok. Vychislyali ploshchad' rany i skorost' ee epitelizacii, v ozhogovoj rane opredelyali chislo TK i intensivnost' degranulyacii, ekspressiyu MMP-9 i VEGF. V dinamike TT absolyutnaya ploshchad' ozhogovoj rany umen'shaetsya na 35%, uvelichivaetsya skorost' ee epitelizacii, v ochage TT uvelichivaetsya chislo TK, izmenyaetsya ih funkcional'naya harakteristika; uvelichivaetsya ekspressiya MMR-9 i VEGF. Vyyavlena obratnaya svyaz' ploshchadi ozhogovoj rany s ekspressiej MMR-9 i VEGF, koefficientom degranulyacii TK. Primenenie MT pri TT vedet k umen'sheniyu ploshchadi ozhogovoj rany, uvelicheniyu skorosti ee epitelizacii, uvelicheniyu v ozhogovoj rane obshchego chisla TK i degranulyacii na 5-e i 10-e sutki, snizheniyu obshchego chisla i degranulyacii TK na 20-e sutki TT (166,87 (154,95; 178;78) ed./mm2; v kontrole — 464,84 (452,92; 476,76) ed./mm2), uvelicheniyu ekspressii MMP-9 na 5-e sutki (14,20 (11,30; 18,10); v kontrole — 3,30 (2,20; 4,40)), ekspressii VEGF na 5-e i 10-e sutki (33,00 (30,20; 34,90); v kontrole — 25,40 (22,20; 29,30)), snizheniyu ekspressii MMP-9 na 10-e i 20-e sutki TT.

Rol' tuchnyh kletok v reparacii kozhi posle termicheskoj travmy pri primenenii dermal'noj plenki s melatoninom