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Nekhvatka informatsii o rasprostranennosti v RF farmakogeneticheskikh markerov privodit k nevozmozhnosti vnedreniya algoritmov personalizatsii, razrabotannykh dlya Zapadnoy Yevropy. Tsel'yu raboty bylo sistematicheskoye izucheniye rasprostranennosti ryada znachimykh farmakogeneticheskikh markerov po vsey territorii Rossii. Iz neskol'kikh massivov populyatsionno-geneticheskikh dannykh otobrany 45 markerov (ADME-genov; genov, kodiruyushchikh farmakodinamicheskiye misheni lekarstvennykh sredstv; genov, kodiruyushchikh komponenty sistemy gemostaza), genotipirovannykh summarno dlya 2197 individov. Opredeleny chastoty etikh markerov v 50 populyatsiyakh, vklyuchayushchikh informatsiyu o 137 etnicheskikh i subetnicheskikh gruppakh. V rezul'tate sozdan farmakogeneticheskiy atlas — sistematicheskoye sobraniye genogeograficheskikh kart rasprostranennosti farmakogeneticheskikh DNK markerov po vsey territorii Rossii i sopredel'nykh stran. Atlas vyyavil tri patterna prostranstvennoy izmenchivosti. Pattern klinal'noy izmenchivosti (gradiyentnogo izmeneniya chastot po osi «vostok–zapad») ob"yedinyayet markery, sleduyushchiye osnovnoy zakonomernosti vsego genofonda naseleniya Severnoy Yevrazii (13% kart atlasa). Pattern ravnomernogo raspredeleniya vydelyayet markery, srednyaya chastota kotorykh kharakterna dlya bol'shinstva regionov Rossii (27% kart atlasa). Pattern «ochagovoy» izmenchivosti ob"yedinyayet farmakogeneticheskiye markery, kharakternyye tol'ko dlya opredelennoy gruppy etnosov i otsutstvuyushchiye v drugikh regionakh (60% kart atlasa). Atlas pokazyvayet, chto srednyaya chastota markera i informatsiya o yego vstrechayemosti v otdel'nykh populyatsiyakh ne mogut sluzhit' ukazaniyem na tip yego raspredeleniya v prostranstve RF — dlya vyyavleniya patterna izmenchivosti neobkhodima genogeograficheskaya karta.

Kartograficheskiy atlas rasprostraneniya 45 farmakogeneticheskikh markerov v narodonaselenii Rossii i sopredel'nykh stran