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Kishechnyy epiteliy postoyanno nakhoditsya v usloviyakh fiziologicheskoy gipoksii. Dopolnitel'naya tkanevaya gipoksiya sposobna privodit' k narusheniyu yego funktsiy i yavlyayetsya priznakom aktivnogo vospalitel'nogo protsessa. V issledovaniyakh in vitro znachitel'nuyu rol' igrayut usloviya kul'tivirovaniya, poskol'ku v svoyu ochered' mogut vliyat' na svoystva kletok. Tsel'yu raboty bylo provesti otsenku ekspressii integrinovykh retseptorov v kletkakh adenokartsinomy tolstogo kishechnika cheloveka Caco-2 pri modelirovanii usloviy gipoksii khloridom kobal'ta (II) i mikrotsirkulyatsii. S pomoshch'yu transkriptomnogo analiza obnaruzheno znachimoye uvelicheniye ekspressii genov a2- i a5-sub"yedinits integrinovykh retseptorov ITGA2 i ITGA5 v usloviyakh gipoksii i umen'sheniye ITGA5 pri inkubirovanii v mikroflyuidnom chipe. Ekspressiya b-sub"yedinits pri etom ne izmenilas'. Pri analize mikroRNK-transkriptomov vyyavleno umen'sheniye ekspressii mikroRNK hsa-miR-766-3p i hsa-miR-23b-5p. V chislo validirovannykh misheney obeikh mikroRNK vkhodit mRNK gena ITGA5. Pokazano, chto mikrotsirkulyatsiya pozvolyayet sozdat' dlya enterotsitov kishechnika usloviya kul'tivirovaniya, boleye blizkiye k fiziologicheskim. Predstavleno obsuzhdeniye vozmozhnogo biologicheskogo znacheniya vyyavlennykh izmeneniy ekspressii profilya integrinov i roli mikrotsirkulyatsii.

Izbiratel'noye izmeneniye ekspressii a-sub"yedinits integrinov v kletkakh kishechnogo epiteliya Caco-2 pri gipoksii v usloviyakh mikrotsirkulyatsii