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Lobno-visochnaya dementsiya (LVD) — neyrodegenerativnoye zabolevaniye, vtoraya po chastote dementsiya s rannim nachalom, proyavlyayushchayasya rechevymi i povedencheskimi narusheniyami. Vyyavleniye patternov atrofii vazhno dlya diagnostiki dannoy patologii. Odnako vizual'naya otsenka dannykh magnitno- rezonansnoy tomografii mozhet byt' nedostatochno chuvstvitel'noy, chto trebuyet ispol'zovaniya ob"yektivnogo metoda opredeleniya ob"yema serogo veshchestva (SV). Tsel'yu issledovaniya bylo otsenit' pattern atrofii SV u patsiyentov s LVD v sravnenii s kontrol'noy gruppoy pri pomoshchi voksel'- oriyentirovannoy morfometrii (VOM). V issledovaniye vklyucheny 16 patsiyentov s LVD (12 — s agrammaticheskim variantom pervichnoy progressiruyushchey afazii (avPPA), tri — s povedencheskim variantom LVD, odin — s logopenicheskim variantom PPA) i 10 zdorovykh dobrovol'tsev. Pri provedenii VOM v gruppe LVD i kontrol'noy gruppe vyyavleno tri statisticheski znachimyye (pFWE-corr &lt; 0,05) zony atrofii — v levoy nizhney lobnoy izviline, levoy fuziformnoy i levoy nadkrayevoy izvilinakh. V svyazi s preobladaniyem v gruppe LVD patsiyentov s avPPA dopolnitel'no provodili VOM v etoy gruppe i gruppe kontrolya, pri kotoroy byl vyyavlen inoy pattern atrofii: umen'sheniye ob"yema SV obnaruzheno v levoy nizhney lobnoy i levoy sredney lobnoy izvilinakh (pFWE-corr &lt; 0,05). Poluchennyye rezul'taty pokazyvayut, chto dlya LVD nezavisimo ot klinicheskogo varianta kharakteren svoy opredelennyy pattetrn atrofii, zakhvatyvayushchiy kak lobno-visochnyye otdely, tak i temennuyu dolyu. Na primere avPPA bylo pokazano, chto u kazhdogo iz variantov zabolevaniya lokalizatsiya atroficheskogo protsessa imeyet otlichnyy ot drugikh kharakter.

Patterny atrofii golovnogo mozga pri lobno-visochnoy dementsii: dannyye voksel'-oriyentirovannoy morfometrii