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Gipoksiya voznikayet v razlichnykh patofiziologicheskikh protsessakh, vklyuchaya progressirovaniye opukholevykh zabolevaniy i metastazirovaniye. Odin iz mekhanizmov molekulyarnogo otveta kletok na gipoksiyu sostoit v rekrutirovanii spetsifichnykh mikroRNK, reguliruyushchikh ekspressiyu svoikh genov-misheney. Tsel'yu raboty bylo otsenit' izmeneniya ekspressii mikroRNK i ikh genov-misheney v kletochnoy linii kolorektal'noy adenokartsinomy cheloveka HT-29 v otvet na gipoksiyu s pomoshch'yu integrirovannogo sekvenirovaniya mikroRNK i mRNK. Dlya modelirovaniya usloviy gipoksii kletki obrabatyvali khloridom kobal'ta (II). Bylo obnaruzheno dostovernoye izmeneniye ekspressii 16 chelovecheskikh mikroRNK, shest' iz nikh (hsa-miR- 18a-5p, hsa-miR-22-3p, hsa-miR-27a-5p, hsa-miR-182-5p, hsa-miR- 215-5p, hsa-miR-425-5p) imeli statisticheski znachimuyu dolyu genov-misheney s protivopolozhnym napravleniyem izmeneniya ekspressii. Na osnovanii bioinformaticheskogo analiza vzaimodeystviy differentsial'no ekspressirovannykh faktorov transkriptsii i mikroRNK byla postroyena vozmozhnaya regulyatornaya set', osnovymi uzlami kotoroy okazalis' HIF-1a, p65, s-Myc i Egr1 (kodiruyemyye genami HIF1A, RELA, MYC i EGR1).

Vzaimosvyaz' izmeneniya ekspressii mikroRNK i mRNK v kletkakh linii nt-29 v usloviyakh gipoksii